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The first is Huppke-Brendel Syndrome, a severe neurodevelopmental disorder characterized by severe intellectual disability, motor deficits, and progressive neurodegeneration

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Figure 1.- Percentage of damage aorta in rabbits fed normal diet alone (group 5) or normal diet plus L-carnitine (group 6) during 65 days of hyperlipidemia regression period

Several mechanisms have been proposed to explain chronic hyperglycemia-induced nerve damage, such as intracellular accumulation of sorbitol, glycation reactions, and oxidative and nitrosative stress (reviewed in 69)